Fragile X syndrome (FXS) is a genetic condition associated with increased risk for social anxiety and avoidance. Using functional near-infrared spectroscopy (fNIRS), we previously demonstrated aberrant neural activity responding to faces in young girls with FXS cross-sectionally. Here, we tested the hypothesis that abnormalities in neural activation and sensitization would increase with age in 65 girls with FXS (ages 6–16 years) relative to an age-matched control group of 52 girls who had comparable cognitive function and clinical symptoms.

中文翻译：

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脆性 X 综合征面部处理过程中功能神经激活和敏化的纵向变化


脆性 X 综合征 （FXS） 是一种与社交焦虑和回避风险增加相关的遗传病。使用功能性近红外光谱 （fNIRS），我们之前在横截面上证明了 FXS 年轻女孩对面部的异常神经活动反应。在这里，我们检验了这样一个假设，即 65 名患有 FXS 的女孩（6-16 岁）的神经激活和致敏异常会随着年龄的增长而增加，相对于年龄匹配的 52 名女孩，这些女孩具有相当的认知功能和临床症状。