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Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
Blood ( IF 21.0 ) Pub Date : 2024-08-09 , DOI: 10.1182/blood.2024024351 Esteban Arrieta-Bolaños 1 , Lars L J van der Burg 2 , Tobias Gedde-Dahl 3 , Marie Robin 4 , Urpu Salmenniemi 5 , Nicolaus Kröger 6 , Ibrahim Yakoub-Agha 7 , Anne Huynh 8 , Charles R Crawley 9 , Eric Deconinick 10 , Claude-Eric Bulabois 11 , Edouard Forcade 12 , Eleni Tholouli 13 , Joost G K van der Hem 2 , Peter van Balen 2 , Jorinde Desiree Hoogenboom 14 , Liesbeth C de Wreede 15 , Florent Malard 16 , Annalisa Ruggeri 16 , Katharina Fleischhauer 1
Blood ( IF 21.0 ) Pub Date : 2024-08-09 , DOI: 10.1182/blood.2024024351 Esteban Arrieta-Bolaños 1 , Lars L J van der Burg 2 , Tobias Gedde-Dahl 3 , Marie Robin 4 , Urpu Salmenniemi 5 , Nicolaus Kröger 6 , Ibrahim Yakoub-Agha 7 , Anne Huynh 8 , Charles R Crawley 9 , Eric Deconinick 10 , Claude-Eric Bulabois 11 , Edouard Forcade 12 , Eleni Tholouli 13 , Joost G K van der Hem 2 , Peter van Balen 2 , Jorinde Desiree Hoogenboom 14 , Liesbeth C de Wreede 15 , Florent Malard 16 , Annalisa Ruggeri 16 , Katharina Fleischhauer 1
Affiliation
HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and noncore subsets. Noncore permissive graft-versus-host mismatches show significantly reduced risks of relapse without increased nonrelapse mortality compared with allele-matched pairs.
中文翻译：
HLA-DP 允许错配的方向性改善了 HCT 对急性白血病和 MDS 的风险预测
HLA-DP 允许错配可以根据它们在核心和非核心亚群之间的免疫肽组分歧分配一个方向。与等位基因匹配的配对相比，非核心允许移植物抗宿主错配显示复发风险显著降低，而非复发死亡率不增加。
更新日期：2024-08-09
中文翻译：
HLA-DP 允许错配的方向性改善了 HCT 对急性白血病和 MDS 的风险预测
HLA-DP 允许错配可以根据它们在核心和非核心亚群之间的免疫肽组分歧分配一个方向。与等位基因匹配的配对相比，非核心允许移植物抗宿主错配显示复发风险显著降低，而非复发死亡率不增加。
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