An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study,Environment International

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An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study
Environment International ( IF 10.3 ) Pub Date : 2024-08-14 , DOI: 10.1016/j.envint.2024.108955
Wil Lieberman-Cribbin ₁ , Arce Domingo-Relloso ₂ , Ronald A Glabonjat ₁ , Kathrin Schilling ₁ , Shelley A Cole ₃ , Marcia O'Leary ₄ , Lyle G Best ₄ , Ying Zhang ₅ , Amanda M Fretts ₆ , Jason G Umans ₇ , Walter Goessler ₈ , Ana Navas-Acien ₁ , Maria Tellez-Plaza ₉ , Allison Kupsco ₁

Affiliation

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.
Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Missouri Breaks Industries Research, Cheyenne River Sioux Tribe, Eagle Butte, SD 57625, USA.
Department of Biostatistics and Epidemiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
MedStar Health Research Institute, Hyattsville, MD, USA; Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA.
Institute of Chemistry, University of Graz, Graz, Austria.
Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Instituto de Salud Carlos III, 28029, Madrid, Spain.

Selenium (Se) is an essential nutrient linked to adverse health endpoints at low and high levels. The mechanisms behind these relationships remain unclear and there is a need to further understand the epigenetic impacts of Se and their relationship to disease. We investigated the association between urinary Se levels and DNA methylation (DNAm) in the Strong Heart Study (SHS), a prospective study of cardiovascular disease (CVD) among American Indians adults.

中文翻译：

强心脏研究中硒状态和 DNA 甲基化的全表观基因组研究

硒 (Se) 是一种必需营养素，低水平和高水平都与不良健康终点相关。这些关系背后的机制尚不清楚，需要进一步了解硒的表观遗传影响及其与疾病的关系。我们在强心脏研究 (SHS) 中研究了尿硒水平与 DNA 甲基化 (DNAm) 之间的关联，该研究是一项针对美国印第安成年人心血管疾病 (CVD) 的前瞻性研究。

更新日期：2024-08-14

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