Herein, magnetic-based biodegradable periodic mesoporous organosilica (BPMO) nanoparticles were successfully synthesized via a co-precipitation method to form a magnetic iron oxide (FeO) core, followed by the condensation of organosilica precursors to produce BPMO shells. The physicochemical properties of the resulting hybrid nanoparticles were evaluated using powder X-ray diffraction, nitrogen adsorption–desorption isotherms, thermogravimetric analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. The synthesized particles exhibited a spherical morphology with an average diameter of approximately 250 nm. A core–shell structure was formed by depositing a 100-nm biodegradable organosilica layer onto the magnetic FeO cluster, endowing the nanoparticles with both magnetic and biodegradable mesoporous characteristics. Notably, despite the silica coating, the saturation magnetization remained high, reaching 35.8 emu/g, suggesting the potential for using these nanoparticles in magnetic-based biomedical applications. Furthermore, FeO@BPMO nanoparticles were demonstrated to be efficiently uptaken by OVCAR8 ovarian cancer cells and spheroids, indicating that these nanoparticles are promising as magnetic nanocarriers for anti-cancer drug delivery and can be used in magnetic resonance imaging and magnetic hyperthermia.

中文翻译：

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用于增强生物医学应用的磁性可生物降解周期性介孔有机二氧化硅纳米颗粒的开发和表征


在此，通过共沉淀法成功合成了基于磁性的可生物降解周期性介孔有机二氧化硅（BPMO）纳米粒子，形成磁性氧化铁（FeO）核，然后将有机二氧化硅前体缩合以产生BPMO壳。使用粉末 X 射线衍射、氮吸附-解吸等温线、热重分析、傅里叶变换红外光谱和振动样品磁力测定法评估所得杂化纳米颗粒的物理化学性质。合成的颗粒呈现球形形态，平均直径约为250 nm。通过在磁性 Fe3O 团簇上沉积 100 nm 可生物降解的有机二氧化硅层形成核壳结构，赋予纳米颗粒同时具有磁性和可生物降解的介孔特性。值得注意的是，尽管有二氧化硅涂层，饱和磁化强度仍然很高，达到 35.8 emu/g，表明这些纳米颗粒在基于磁性的生物医学应用中具有潜力。此外，Fe3O@BPMO纳米颗粒被证明可以被OVCAR8卵巢癌细胞和球体有效摄取，表明这些纳米颗粒有望作为抗癌药物递送的磁性纳米载体，并可用于磁共振成像和磁热疗。