PAX6 is a key regulator of eye development and epithelial homeostasis in the cornea. When deficient, chronic corneal inflammation, neovascularization and limbal stem cell deficiency can occur. Here we investigated the potential of duloxetine, a generic serotonin reuptake inhibitor that can upregulate PAX6 in vitro, for its in vivo activity in the context of corneal inflammation.

中文翻译：

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度洛西汀增强小鼠 LPS 诱导的角膜炎症中的 PAX6 表达并抑制先天免疫反应


PAX6 是角膜中眼睛发育和上皮稳态的关键调节因子。当缺乏时，可能会出现慢性角膜炎症、新生血管形成和角膜缘干细胞缺乏症。在这里，我们研究了度洛西汀的潜力，度洛西汀是一种通用的 5-羟色胺再摄取抑制剂，可以在体外上调 PAX6，因为它在角膜炎症的情况下具有体内活性。