Ocular surface disease (OSD) is a complex condition that can cause a range of symptoms (e.g, dryness, irritation, and pain) and can significantly impact the quality of life of affected individuals. Iatrogenic OSD, a common finding in patients with glaucoma who receive chronic therapy with topical ocular antihypertensive drugs containing preservatives such as benzalkonium chloride (BAK), has been linked to damage to the ocular surface barrier, corneal epithelial cells, nerves, conjunctival goblet cells, and trabecular meshwork. Chronic BAK exposure activates inflammatory pathways and worsens symptoms, compromising the success of subsequent filtration surgery in an exposure-dependent manner.

中文翻译：

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防腐剂与眼表疾病：综述


眼表疾病 (OSD) 是一种复杂的疾病，可引起一系列症状（例如干燥、刺激和疼痛），并可显着影响受影响个体的生活质量。医源性 OSD 是接受含有苯扎氯铵 (BAK) 等防腐剂的局部眼部抗高血压药物长期治疗的青光眼患者的常见症状，与眼表屏障、角膜上皮细胞、神经、结膜杯状细胞、和小梁网。慢性 BAK 暴露会激活炎症途径并使症状恶化，从而以暴露依赖性方式损害后续滤过手术的成功。