Currently, lung transplantation outcome remains inferior compared to other solid organ transplantations. A major cause for limited survival after lung transplantation is chronic lung allograft dysfunction. Numerous animal models have been developed to investigate chronic lung allograft dysfunction to discover adequate treatments. The murine orthotopic lung transplant model has been further optimized over the last years. However, different degrees of genetic mismatch between donor and recipient mice have been used, applying a single, minor, moderate, and major genetic mismatch. This review aims to reassess the existing murine mismatch models and provide a comprehensive overview, with a specific focus on their eventual histopathological presentation. This will be crucial to leverage this model and tailor it according to specific research needs.

中文翻译：

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小鼠原位肺移植模型：遗传错配程度的全面概述和慢性肺同种异体移植功能障碍的组织病理学见解


目前，与其他实体器官移植相比，肺移植结果仍然较差。肺移植术后生存受限的一个主要原因是慢性肺同种异体移植物功能障碍。已经开发了许多动物模型来研究慢性肺同种异体移植物功能障碍，以发现适当的治疗方法。小鼠原位肺移植模型在过去几年中得到了进一步优化。然而，供体小鼠和受体小鼠之间使用了不同程度的遗传错配，应用单一、轻微、中等和主要的遗传错配。本综述旨在重新评估现有的小鼠错配模型并提供全面的概述，特别关注其最终的组织病理学表现。这对于利用此模型并根据特定研究需求进行定制至关重要。