Patients with type 1 diabetes and concurrent subcutaneous insulin resistance present unique diagnostic and therapeutic challenges for clinicians. The standard therapeutic approach is the administration of intravenous insulin. Pancreatic transplantation should be considered at an appropriate time, particularly in the event of life-threatening ketoacidosis, hyperglycemia, hypoglycemia, catheter-associated thrombosis, and infections. We present the case of a 24-year-old woman with type 1 diabetes since early childhood and increasingly uncontrollable subcutaneous and intramuscular insulin resistance. Furthermore, we present the diagnostic pathway and therapeutic interventions performed, culminating in pancreatic transplantation as a curative approach. Immediate graft function resulted in optimal glycemic control.

中文翻译：

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胰腺移植作为合并皮下胰岛素抵抗的 1 型糖尿病患者的挽救治疗


1 型糖尿病患者合并皮下胰岛素抵抗，给临床医生带来了独特的诊断和治疗挑战。标准的治疗方法是静脉注射胰岛素。应在适当的时候考虑胰腺移植，尤其是在出现危及生命的酮症酸中毒、高血糖、低血糖、导管相关血栓形成和感染的情况下。我们介绍了一名 24 岁女性从儿童早期开始患有 1 型糖尿病并且越来越难以控制的皮下和肌内胰岛素抵抗的病例。此外，我们介绍了诊断途径和进行的治疗干预，最终以胰腺移植作为一种治疗方法。即刻移植物功能导致最佳血糖控制。