Reaction and separation of complex azeotropic systems in reactive distillation processes are difficult to optimize simultaneously, which severely hinders the economic performance of the process. This study focused on the nonlinear relationship between product separation sequence and reaction evaluation indexes (yield, productivity and selectivity) under different pressures. Based on thermodynamic methods and phase diagram analysis, initial processes for intensified reactive distillation at four pressures were designed. Quantum chemistry, toxicity and relative volatility were used to select the best extractant. The multi-objective genetic algorithm was used to optimize different operating variables. Heat integration technology was presented to reduce process energy consumption. By comparing synthesis and purification processes of isobutyl formate with different feed ratios, it was found that the higher the pressure, the better the product separation sequence, the more conducive it is to reaction separation, and the higher the process profit.

中文翻译：

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不同压力下分离顺序对反应精馏耦合萃取精馏的影响


反应精馏过程中复杂共沸体系的反应和分离很难同时优化，这严重阻碍了该过程的经济性能。本研究主要研究不同压力下产物分离序列与反应评价指标（收率、生产率和选择性）之间的非线性关系。基于热力学方法和相图分析，设计了四种压力下强化反应精馏的初始工艺。使用量子化学、毒性和相对挥发性来选择最佳萃取剂。多目标遗传算法用于优化不同的操作变量。提出热集成技术以降低工艺能耗。通过比较不同投料比的甲酸异丁酯合成及纯化工艺发现，压力越高，产品分离顺序越好，越有利于反应分离，工艺利润越高。