International consensus supports the development of standardized protocols for measured glomerular filtration rate (mGFR) to facilitate the integration of mGFR testing in both clinical and research settings. To this end, the European Kidney Function Consortium convened an international group of experts with relevant experience in mGFR. The working group performed an extensive literature search to inform the development of recommendations for mGFR determination using 1-compartment plasma clearance models and iohexol as the exogenous filtration marker. Iohexol was selected as it is non–radio labeled, inexpensive, and safe, can be assayed at a central laboratory, and the other commonly used non–radio-labeled tracers have been (inulin) or are soon to be (iothalamate) discontinued. A plasma clearance model was selected over urine clearance as it requires no urine collection. A 1 compartment was preferred to 2 compartments as it requires fewer samples. The recommendations are based on published evidence complemented by expert opinion. The consensus paper covers practical advice for patients and health professionals, preparation, administration, and safety aspects of iohexol, laboratory analysis, blood sample collection and sampling times using both multiple and single-sample protocols, description of the mGFR mathematical calculations, as well as implementation strategies. Supplementary materials include patient and provider information sheets, standard operating procedures, a study protocol template, and support for mGFR calculation.

中文翻译：

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成人 Iohexol 血浆清除率测量方案标准化：欧洲肾功能联盟的共识文件


国际共识支持制定测量肾小球滤过率 （mGFR） 的标准化方案，以促进 mGFR 检测在临床和研究环境中的整合。为此，欧洲肾功能联盟召集了一个具有 mGFR 相关经验的国际专家组。工作组进行了广泛的文献检索，为使用 1 室血浆清除模型和碘海醇作为外源性滤过标志物测定 mGFR 的建议制定提供信息。选择 Iohexol 是因为它非放射性标记、廉价且安全，可以在中心实验室进行检测，并且其他常用的非放射性标记示踪剂已经（菊粉）或即将停用（碘酞酸盐）。选择血浆清除率模型而不是尿液清除率模型，因为它不需要收集尿液。1 个隔室优于 2 个隔室，因为它需要的样品更少。这些建议基于已发表的证据，并辅以专家意见。共识文件涵盖了对患者和卫生专业人员的实用建议、碘海醇的准备、给药和安全方面、实验室分析、使用多样本和单样本方案的血样采集和采样时间、mGFR 数学计算的描述以及实施策略。补充材料包括患者和提供者信息表、标准操作程序、研究方案模板以及对 mGFR 计算的支持。