Regulating Charge Transfer in Cyanine Dyes: A Universal Methodology for Enhancing Cancer Phototherapeutic Efficacy,Accounts of Chemical Research

当前位置： X-MOL 学术 › Acc. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Regulating Charge Transfer in Cyanine Dyes: A Universal Methodology for Enhancing Cancer Phototherapeutic Efficacy
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2024-08-17 , DOI: 10.1021/acs.accounts.4c00399
Xueze Zhao _{1,

2} , Jianjun Du ₁ , Wen Sun ₁ , Jiangli Fan _{1,

3} , Xiaojun Peng ₁

Affiliation

Due to the advantages of spatiotemporal selectivity and inherent noninvasiveness, cancer phototherapy, which includes both photodynamic therapy (PDT) and photothermal therapy (PTT), has garnered significant attention in recent years as a promising cancer treatment. Despite the commendable progress in this field, persistent challenges remain. In PDT, limitations in dyes manifest as low intersystem crossing (ISC) efficiency and oxygen-dependent photoactivity, resulting in unsatisfactory performance, particularly under hypoxic conditions. Similarly, PTT encounters consistent insufficiencies in the photothermal conversion efficiency (PCE) of dyes. Additionally, the suboptimal phototherapeutic efficacy often exhibits a limited immune response. These factors collectively impose significant constraints on phototherapy in oncological applications, leading to limited tumor inhibition, tumor recurrence, and even metastasis.

中文翻译：

调节花青染料中的电荷转移：增强癌症光疗功效的通用方法

由于时空选择性和固有的非侵入性的优势，癌症光疗，包括光动力疗法（PDT）和光热疗法（PTT），作为一种有前途的癌症治疗方法近年来引起了人们的广泛关注。尽管这一领域取得了值得称赞的进展，但挑战依然存在。在 PDT 中，染料的局限性表现为较低的系间窜越 (ISC) 效率和氧依赖性光活性，导致性能不令人满意，特别是在缺氧条件下。同样，PTT 的染料光热转换效率 (PCE) 也一直存在不足。此外，次优的光疗功效通常表现出有限的免疫反应。这些因素共同对光疗在肿瘤学中的应用产生了重大限制，导致肿瘤抑制有限、肿瘤复发甚至转移。

更新日期：2024-08-17

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南