The goal of the Biostatistics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been to ensure that sound study designs and statistical methods are used to meet the overall goals of ADNI. We have supported the creation of a well-validated and well-curated longitudinal database of clinical and biomarker information on ADNI participants and helped to make this accessible and usable for researchers. We have developed a statistical methodology for characterizing the trajectories of clinical and biomarker change for ADNI participants across the spectrum from cognitively normal to dementia, including multivariate patterns and evidence for heterogeneity in cognitive aging. We have applied these methods and adapted them to improve clinical trial design. ADNI-4 will offer us a chance to help extend these efforts to a more diverse cohort with an even richer panel of biomarker data to support better knowledge of and treatment for Alzheimer's disease and related dementias.

中文翻译：

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ADNI 生物统计学核心的贡献


阿尔茨海默病神经影像学计划 （ADNI） 的生物统计学核心的目标是确保使用合理的研究设计和统计方法来满足 ADNI 的总体目标。我们支持创建一个经过充分验证和精心策划的 ADNI 参与者临床和生物标志物信息的纵向数据库，并帮助研究人员访问和使用这些信息。我们开发了一种统计方法，用于描述ADNI参与者从认知正常到痴呆的临床和生物标志物变化轨迹，包括多变量模式和认知衰老异质性的证据。我们应用了这些方法，并对其进行了调整以改进临床试验设计。ADNI-4 将为我们提供一个机会，通过更丰富的生物标志物数据来帮助将这些工作扩展到更多样化的队列，以支持对阿尔茨海默病和相关痴呆症的更好了解和治疗。