Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome,Annals of the New York Academy of Sciences

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Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2024-08-16 , DOI: 10.1111/nyas.15205
Carlos Gómez-Martínez _{1,

2,

3} , Nancy Babio _{1,

2,

3} , Lucía Camacho-Barcia _{3,

4,

5} , Jordi Júlvez ₆ , Stephanie K Nishi _{1,

2,

3,

7,

8} , Zenaida Vázquez _{3,

9} , Laura Forcano ₁₀ , Andrea Álvarez-Sala _{3,

11} , Aida Cuenca-Royo ₁₀ , Rafael de la Torre _{3,

10,

12} , Marta Fanlo-Maresma _{3,

13} , Susanna Tello ₁₀ , Dolores Corella _{3,

11} , Alejandro Arias Vásquez _{14,

15} , Søren Dalsgaard _{16,

17} , Barbara Franke _{14,

15} , Fernando Fernández-Aranda _{3,

4,

18} , Jordi Salas-Salvadó _{1,

2,

3}

Affiliation

Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia. Grup d'Alimentació, Nutrició, Desenvolupament i Salut Mental (ANUT-DSM), Unitat de Nutrició Humana, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus, Spain.
Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Department of Clinical Psychology, Bellvitge University Hospital, Barcelona, Spain.
Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Clinical and Epidemiological Neuroscience Group (NeuroÈpia), Reus, Spain.
Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Toronto, Ontario, Canada.
Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Department of Preventive Medicine and Public Health, Instituto de Investigación Sanitaria de Navarra (IdISNA), University of Navarra, Pamplona, Spain.
Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Department of Preventive Medicine, University of Valencia, Valencia, Spain.
Faculty of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IBIDELL, Hospitalet de Llobregat, Barcelona, Spain.
Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.

Impulsivity has been proposed to have an impact on glycemic dysregulation. However, it remains uncertain whether an unfavorable glycemic status could also contribute to an increase in impulsivity levels. This study aims to analyze associations of baseline and time‐varying glycemic status with 3‐year time‐varying impulsivity in older adults at high risk of cardiovascular disease. A 3‐year prospective cohort design was conducted within the PREDIMED‐Plus‐Cognition substudy. The total population includes 487 participants (mean age = 65.2 years; female = 50.5%) with overweight or obesity and metabolic syndrome. Insulin resistance (HOMA‐IR), glycated hemoglobin (HbA1c), presence of type 2 diabetes mellitus, and type 2 diabetes control were evaluated. Impulsivity was measured using the Impulsive Behavior Scale questionnaire and various cognitive measurements. Impulsivity z‐scores were generated to obtain Global, Trait, and Behavioral Impulsivity domains. Linear mixed models were used to study the longitudinal associations across baseline, 1‐year, and 3‐year follow‐up visits. HOMA‐IR was not significantly related to impulsivity. Participants with higher HbA1c levels, type 2 diabetes, and poor control of diabetes showed positive associations with the Global Impulsivity domain over time, and those with higher HbA1c levels were further related to increases in the Trait and Behavioral Impulsivity domains over the follow‐up visits. These results suggest a potential positive feedback loop between impulsivity and glycemic‐related dysregulation.

中文翻译：

糖化血红蛋白、2 型糖尿病和糖尿病控制不良与超重或肥胖和代谢综合征老年人的冲动变化呈正相关

有人提出冲动会对血糖失调产生影响。然而，目前尚不确定不利的血糖状态是否也会导致冲动水平的增加。本研究旨在分析心血管疾病高危老年人的基线和随时间变化的血糖状态与 3 年随时间变化的冲动性之间的关系。 PREDIMED-Plus-Cognition 子研究中进行了一项为期 3 年的前瞻性队列设计。总人口包括 487 名患有超重或肥胖以及代谢综合征的参与者（平均年龄 = 65.2 岁；女性 = 50.5%）。评估了胰岛素抵抗 (HOMA-IR)、糖化血红蛋白 (HbA1c)、是否存在 2 型糖尿病以及 2 型糖尿病控制情况。使用冲动行为量表问卷和各种认知测量来测量冲动。生成冲动 z 分数以获得全局、特质和行为冲动领域。线性混合模型用于研究基线、1 年和 3 年随访的纵向关联。 HOMA-IR 与冲动性没有显着相关。随着时间的推移，HbA1c 水平较高、2 型糖尿病和糖尿病控制不佳的参与者与整体冲动域呈正相关，而 HbA1c 水平较高的参与者在随访期间与特质和行为冲动域的增加进一步相关。这些结果表明冲动和血糖相关失调之间存在潜在的正反馈循环。

更新日期：2024-08-16

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