Objective Concerns exist about the possible detrimental effects of exercise training on aortic size and valve function in individuals with bicuspid aortic valve (BAV). This multicentre international study aimed to determine the characteristics of aortic size and valve function in athletes versus non-athletes with BAV and athletes with tricuspid aortic valve (TAV). Methods We enrolled competitive athletes with BAV and age- and sex-matched athletes with TAV and non-athletes with BAV. We assessed valve function, aortic size and biventricular measures using echocardiography. Individuals with established moderate-severe AV stenosis, regurgitation or significant aortic dilation were excluded from the study. Results The study population comprised 504 participants: 186 competitive athletes with BAV (84% males; age 30±11 years), 193 competitive athletes with TAV and 125 non-athletes with BAV. The aortic annulus was greater in athletes with BAV than athletes with TAV and non-athletes with BAV (p<0.001). Both athletic and non-athletic individuals with BAV had greater sinuses of Valsalva, sino-tubular junction and ascending aorta diameters than athletes with TAV (p<0.001). However, no significant differences were found between athletes and non-athletes with BAV. Left ventricular index volumes and mass were greater in athletes with BAV than in the other two groups (p<0.001). Individuals with BAV (athletes and non-athletes) had greater mean gradients than TAV athletes. Conclusion This multicentre international study demonstrates no differences between athletes with BAV and non-athletes with BAV regarding aortic valve function or aortic dimensions. However, athletes with BAV have larger aortic diameters and a relatively worse valvular function than athletes with TAV. Data are available upon reasonable request.

中文翻译：

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运动实践及其对二叶式主动脉瓣疾病主动脉大小和瓣膜功能的影响：来自 SPREAD 研究的横断面报告


目的 存在关于运动训练对二叶式主动脉瓣 （BAV） 个体主动脉大小和瓣膜功能可能产生的有害影响的担忧。这项多中心国际研究旨在确定运动员与非 BAV 运动员和三尖瓣主动脉瓣 （TAV） 运动员的主动脉大小和瓣膜功能的特征。方法 我们招募了患有 BAV 的竞技运动员和年龄和性别匹配的运动员患有 TAV 以及患有 BAV 的非运动员。我们使用超声心动图评估了瓣膜功能、主动脉大小和双心室测量值。已确诊中重度房室狭窄、反流或显着主动脉扩张的个体被排除在研究之外。结果 研究人群包括 504 名参与者：186 名患有 BAV 的竞技运动员（84% 为男性;年龄 30±11 岁），193 名患有 TAV 的竞技运动员和 125 名患有 BAV 的非运动员。BAV 运动员的主动脉瓣环大于 TAV 运动员和非 BAV 运动员 （p<0.001）。与 TAV 运动员相比，患有 BAV 的运动和非运动个体的 Valsalva 窦、窦管交界处和升主动脉直径更大 （p<0.001）。然而，在患有 BAV 的运动员和非运动员之间没有发现显著差异。BAV 运动员的左心室指数体积和质量大于其他两组 （p<0.001）。BAV 个体 （运动员和非运动员） 的平均梯度大于 TAV 运动员。结论 这项多中心国际研究表明，患有 BAV 的运动员和非患有 BAV 的运动员在主动脉瓣功能或主动脉尺寸方面没有差异。然而，与 TAV 运动员相比，患有 BAV 的运动员的主动脉直径更大，瓣膜功能相对较差。 数据可根据合理要求提供。