<br>聚合物心脏瓣膜的最新进展：从基础研究到临床试验,Materials Today Bio

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聚合物心脏瓣膜的最新进展：从基础研究到临床试验
Materials Today Bio ( IF 8.7 ) Pub Date : 2024-08-10 , DOI: 10.1016/j.mtbio.2024.101194
Yuanchi Wang ₁ , Yulong Fu ₁ , Qingyu Wang ₁ , Deling Kong ₂ , Zhihong Wang ₃ , Jing Liu ₁

Affiliation

心脏瓣膜病（VHD）已成为全球最普遍的心脏病之一，人工瓣膜置换术是有效的治疗方法之一。随着微创技术的快速发展，经导管瓣膜置换术近年来一直在探索，如经导管主动脉瓣置换术（TAVR）技术。此外，人工瓣膜的基础研究已经开始从传统的机械瓣膜和生物瓣膜转向聚合物心脏瓣膜的开发。聚合物心脏瓣膜（PHV）因其更长的耐用性、更好的生物相容性和更低的成本等优点而显示出光明的前景。本文简要介绍了聚合物心脏瓣膜的发展历史，总结了适用于心脏瓣叶的高分子材料类型以及基础研究中新兴的聚合物心脏瓣膜加工/制备方法。此外，我们促进了对目前临床前/临床研究中的聚合物心脏瓣膜产品的更深入理解，并总结了当前研究的局限性以及未来的发展趋势。因此，本文将为人工瓣膜领域的研究人员提供整体理解，并为具有更好耐用性和生物相容性的瓣膜的设计和研究提供思路。

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Recent advancements in polymeric heart valves: From basic research to clinical trials

Valvular heart diseases (VHDs) have become one of the most prevalent heart diseases worldwide, and prosthetic valve replacement is one of the effective treatments. With the fast development of minimal invasive technology, transcatheter valves replacement has been exploring in recent years, such as transcatheter aortic valve replacement (TAVR) technology. In addition, basic research on prosthetic valves has begun to shift from traditional mechanical valves and biological valves to the development of polymeric heart valves. The polymeric heart valves (PHVs) have shown a bright future due to their advantages of longer durability, better biocompatibility and reduced cost. This review gives a brief history of the development of polymeric heart valves, provides a summary of the types of polymer materials suitable for heart leaflets and the emerging processing/preparation methods for polymeric heart valves in the basic research. Besides, we facilitate a deeper understanding of polymeric heart valve products that are currently in preclinical/clinical studies, also summary the limitations of the present researches as well as the future development trends. Hence, this review will provide a holistic understanding for researchers working in the field of prosthetic valves, and will offer ideas for the design and research of valves with better durability and biocompatibility.

更新日期：2024-08-10

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