The purpose of this study is to systematically study and analyse the dose calibration and measurement of the alanine/electron spin resonance dosimetry system in FLASH radiotherapy. The dose calibration curve of the alanine dosimeter ranged from 0 to 50 Gy, and the best linear fit to the data shows a correlation coefficient close to 1. In the stability experiment, the preset irradiation values for the alanine dosimeter and radiochromic film were 14.34 Gy and 13.38 Gy, respectively, and the results of a stability experiment results showed that the alanine dosimeter exhibited superior stability, compared with radiochromic film, with a deviation of less than 1% in repeated measurements. The results of X-ray FLASH irradiation experiments on mice showed that the maximum standard errors of the alanine dosimeter between the measured results and the preset dose values were 4.57% (chest experiment) and 3.22% (abdomen experiment), whereas those for the radiochromic film were 6.03% (chest experiment) and 6.50% (abdomen experiment). Additionally, X-ray and electron-beam FLASH radiotherapy experiments on mice verified that the alanine dosimeter showed no dose-rate dependence and provided more accurate measurement results compared to the radiochromic film.

中文翻译：

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用于 FLASH 放射治疗的丙氨酸/电子自旋共振剂量测定


本研究的目的是系统地研究和分析丙氨酸/电子自旋共振剂量测量系统在FLASH放疗中的剂量校准和测量。丙氨酸剂量计的剂量校准曲线范围为0～50 Gy，与数据的最佳线性拟合显示相关系数接近1。在稳定性实验中，丙氨酸剂量计和放射变色膜的预设照射值为14.34 Gy分别为13.38 Gy和13.38 Gy，稳定性实验结果表明，与放射致色膜相比，丙氨酸剂量计表现出优异的稳定性，重复测量偏差小于1%。对小鼠进行X射线FLASH照射实验结果表明，丙氨酸剂量计测量结果与预设剂量值之间的最大标准误差分别为4.57%（胸部实验）和3.22%（腹部实验），而放射致色剂量计的测量结果与预设剂量值之间的最大标准误差分别为4.57%（胸部实验）和3.22%（腹部实验）。胶片分别为6.03%（胸部实验）和6.50%（腹部实验）。此外，对小鼠进行的 X 射线和电子束 FLASH 放射治疗实验证实，丙氨酸剂量计不存在剂量率依赖性，并且与放射变色胶片相比，提供了更准确的测量结果。