Chemical Mechanisms and Biological Effects of Chiral Nanomaterials,Accounts of Materials Research

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Chemical Mechanisms and Biological Effects of Chiral Nanomaterials
Accounts of Materials Research ( IF 14.0 ) Pub Date : 2024-08-16 , DOI: 10.1021/accountsmr.4c00158
Gaoyang Wang ₁ , Aihua Qu ₁ , Maozhong Sun ₁ , Jun Xu ₂ , Hua Kuang ₁

Affiliation

Chirality exerts significant roles in biological systems and physiological processes; amino acids, sugars, peptides with multilevel structures, macromolecular proteins, and nucleic acids are all known to exhibit a single chiral structure. The characteristics of intrinsic chirality in a biological system determine the specificity of interactions between biomolecules and also influence a series of key processes in biological systems. Consequently, investigating chirality and the biogenesis of life is critical if we are to understand how the human body works. Although the influential role of chiral materials on biological processes has been investigated for several decades, the specific relationships between chirality and biological functionality have yet to be determined. In order to elucidate the specific role played by chirality in living processes, researchers have tended to focus on three essential aspects: (1) the origin of chirality and breaking the symmetry of life; (2) the amplification of chirality and the realization of high levels of homogeneous chirality in living systems, and (3) chirality transfer mechanisms in vivo.

中文翻译：

手性纳米材料的化学机理和生物效应

手性在生物系统和生理过程中发挥着重要作用;已知氨基酸、糖、具有多级结构的肽、大分子蛋白和核酸都表现出单一的手性结构。生物系统中内在手性的特征决定了生物分子之间相互作用的特异性，也影响了生物系统中的一系列关键过程。因此，如果我们要了解人体的工作原理，研究手性和生命的生物发生至关重要。尽管手性材料对生物过程的影响作用已经研究了几十年，但手性与生物功能之间的具体关系尚未确定。为了阐明手性在生命过程中所起的具体作用，研究人员倾向于关注三个基本方面：（1）手性的起源和打破生命对称性;（2）在生命系统中手性的放大和高水平的均匀手性实现，以及（3）体内的手性转移机制。

更新日期：2024-08-16

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