Memory consolidation involves the synchronous reactivation of hippocampal cells active during recent experience in sleep sharp-wave ripples (SWRs). How this increase in firing rates and synchrony after learning is counterbalanced to preserve network stability is not understood. We discovered a network event generated by an intrahippocampal circuit formed by a subset of CA2 pyramidal cells to cholecystokinin-expressing (CCK+) basket cells, which fire a barrage of action potentials (“BARR”) during non–rapid eye movement sleep. CA1 neurons and assemblies that increased their activity during learning were reactivated during SWRs but inhibited during BARRs. The initial increase in reactivation during SWRs returned to baseline through sleep. This trend was abolished by silencing CCK+ basket cells during BARRs, resulting in higher synchrony of CA1 assemblies and impaired memory consolidation.

中文翻译：

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睡眠期间平衡记忆重新激活的海马回路机制


记忆巩固涉及最近经历的睡眠尖波波纹（SWR）期间活跃的海马细胞的同步重新激活。目前尚不清楚学习后如何平衡发射率和同步性的增加以保持网络稳定性。我们发现了一个由 CA2 锥体细胞子集到表达胆囊收缩素 (CCK+) 篮子细胞形成的海马内回路产生的网络事件，这些细胞在非快速眼动睡眠期间会激发一系列动作电位 (“BARR”)。在学习过程中增加活动的 CA1 神经元和组件在 SWR 期间被重新激活，但在 BARR 期间被抑制。 SWR 期间重新激活的最初增加通过睡眠恢复到基线。通过在 BARR 期间沉默 CCK+ 篮状细胞，可以消除这种趋势，从而提高 CA1 组装的同步性并损害记忆巩固。