BackgroundThe genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?MethodsWe mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255–6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.ResultsOur results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p‐value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.ConclusionsThese findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.

中文翻译：

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绘制单个城市地区多基因评分与自闭症和多动症特征的关联


背景已知自闭症和注意力缺陷多动障碍 (ADHD) 特征的遗传和环境病因在空间上存在差异，但这是否会转化为特定常见遗传变异关联的变化？雅芳父母和儿童纵向研究中的特征（氮= 4,255–6,165）在英国布里斯托尔周边地区，并将它们与与自闭症和多动症患病率相关的环境地图进行比较。结果我们的结果表明遗传关联在空间上存在差异，在不同条件下构建的多基因评分中自闭症特征的模式一致p ‐值阈值。 ADHD 特征的模式在不同阈值之间变化更大。我们发现空间分布通常与已知的环境影响相关。结论这些发现揭示了导致自闭症和多动症特征中环境与遗传影响之间复杂相互作用的因素。