Artificial boron enzymes,Nature Chemical Biology

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Artificial boron enzymes
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2024-08-16 , DOI: 10.1038/s41589-024-01707-0
Xiao-Wang Chen ₁ , Zhiyu Bo ₁ , Yang Yang _{1,

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Affiliation

Boron is a common element found in various minerals; however, it is not used in life-creating machinery in nature. In a new study, boron enzymes have been created by introducing a boronic acid-containing non-canonical amino acid into an artificial enzyme scaffold. Further development via directed evolution enabled the selection of new-to-nature stereoselective chemistry.

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