The Alzheimer's Disease Neuroimaging Initiative (ADNI) has revolutionized the landscape of Alzheimer's research through its Informatics Core, which has facilitated unprecedented data standardization and sharing. Over 20 years, ADNI established a robust informatics framework, enabling the validation of biomarkers and supporting global research efforts. The Informatics Core, centered at the Laboratory of Neuro Imaging (LONI), provides a comprehensive data hub that ensures data quality, accessibility, and security, fostering over 5600 publications and significant scientific advancements. By embracing open data sharing principles, ADNI set a gold standard in data transparency, allowing over 26,000 investigators from 169 countries to access and download a wealth of multimodal data. This collaborative approach not only accelerated biomarker discovery and drug development and advanced our understanding of Alzheimer's disease but also has served as a model for other research initiatives, demonstrating the transformative potential of carefully designed informatics models and shared data in driving global scientific progress.

中文翻译：

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 ADNI 的信息学


阿尔茨海默病神经影像学计划 （ADNI） 通过其信息学核心彻底改变了阿尔茨海默病研究的格局，该核心促进了前所未有的数据标准化和共享。20 多年来，ADNI 建立了一个强大的信息学框架，能够验证生物标志物并支持全球研究工作。信息学核心以神经影像实验室 （LONI） 为中心，提供了一个全面的数据中心，可确保数据质量、可访问性和安全性，促进了 5600 多篇出版物和重大科学进步。通过采用开放数据共享原则，ADNI 在数据透明度方面树立了黄金标准，允许来自 169 个国家/地区的 26,000 多名研究人员访问和下载大量多模式数据。这种协作方法不仅加速了生物标志物的发现和药物开发，增进了我们对阿尔茨海默病的理解，而且还成为其他研究计划的模型，展示了精心设计的信息学模型和共享数据在推动全球科学进步方面的变革潜力。