The Alzheimer's Disease Neuroimaging Initiative (ADNI) Clinical Core is responsible for coordination of all clinical activities at the ADNI sites, including project management, regulatory oversight, and site management and monitoring, as well as the collection of all clinical data and management of all study data. The Clinical Core is also charged with determining the clinical classifications and criteria for enrollment in evolving AD trials and enabling the ongoing characterization of the cross-sectional features and longitudinal trajectories of the ADNI cohorts with application of these findings to optimal clinical trial designs. More than 2400 individuals have been enrolled in the cohorts since the inception of ADNI, facilitating refinement of our understanding of the AD trajectory and allowing academic and industry investigators to model therapeutic trials across the disease spectrum from the presymptomatic stage through dementia.

中文翻译：

---

阿尔茨海默病神经影像学计划临床核心


阿尔茨海默病神经影像学计划 （ADNI） 临床核心负责协调 ADNI 站点的所有临床活动，包括项目管理、监管监督、站点管理和监测，以及所有临床数据的收集和所有研究数据的管理。临床核心还负责确定临床分类和纳入不断发展的 AD 试验的标准，并能够持续表征 ADNI 队列的横断面特征和纵向轨迹，并将这些发现应用于最佳临床试验设计。自 ADNI 成立以来，已有 2400 多人被纳入队列，这有助于完善我们对 AD 轨迹的理解，并允许学术和行业研究人员对从症状前阶段到痴呆的疾病范围内的治疗试验进行建模。