Based on current international guidelines, pulmonary arterial wedge pressure (PAWP) is critical for differentiating between pre- and post-capillary pulmonary hypertension (PH) and plays an important role in the diagnosis of left heart failure [1, 2]. The current PAWP threshold to define post-capillary PH is >15 mmHg, measured by right heart catheterisation (RHC) in the supine position [1]. Historical data suggest that the upper limit of physiological PAWP may be lower [3–5], although no systematic review and meta-analysis has investigated the normal range of PAWP considering major confounding factors. We aimed to fill this knowledge gap by assessing the normal value of PAWP based on the largest available database of the published literature on pulmonary haemodynamics, also taking into account possible confounding factors, such as age, sex and RHC methodology.

根据当前的国际指南，肺动脉楔压 （PAWP） 对于区分毛细血管前和毛细血管后肺动脉高压 （PH） 至关重要，并且在左心衰竭的诊断中起着重要作用 [1， 2]。目前定义毛细血管后 PH 的 PAWP 阈值为 >15 mmHg，通过在仰卧位的右心导管插入术 （RHC） 测量 [1]。历史数据表明，生理性 PAWP 的上限可能更低 [3-5]，尽管没有系统评价和荟萃分析调查考虑主要混杂因素的 PAWP 的正常范围。我们旨在通过根据已发表的肺血流动力学文献的最大可用数据库评估 PAWP 的正常值来填补这一知识空白，同时考虑可能的混杂因素，例如年龄、性别和 RHC 方法。