International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents,Nature Reviews Endocrinology

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International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2024-08-15 , DOI: 10.1038/s41574-024-01024-5
Ruth T Casey _{1,

2} , Emile Hendriks ₃ , Cheri Deal ₄ , Steven G Waguespack ₅ , Verena Wiegering ₆ , Antje Redlich ₇ , Scott Akker ₈ , Rathi Prasad ₉ , Martin Fassnacht ₁₀ , Roderick Clifton-Bligh ₁₁ , Laurence Amar _{12,

13} , Stefan Bornstein ₁₄ , Letizia Canu _{15,

16} , Evangelia Charmandari ₁₇ , Alexandra Chrisoulidou ₁₈ , Maria Currás Freixes ₁₉ , Ronald de Krijger _{20,

21} , Luisa de Sanctis ₂₂ , Antonio Fojo ₂₃ , Amol J Ghia ₂₄ , Angela Huebner ₂₅ , Vasilis Kosmoliaptsis _{26,

27} , Michaela Kuhlen ₂₈ , Marco Raffaelli _{29,

30} , Charlotte Lussey-Lepoutre ₃₁ , Stephen D Marks ₃₂ , Naris Nilubol ₃₃ , Mirko Parasiliti-Caprino ₃₄ , Henri H J L M Timmers ₃₅ , Anna Lena Zietlow ₃₆ , Mercedes Robledo ₁₉ , Anne-Paule Gimenez-Roqueplo _{37,

38} , Ashley B Grossman _{39,

40,

41} , David Taïeb ₄₂ , Eamonn R Maher ₁ , Jacques W M Lenders ₃₅ , Graeme Eisenhofer ₁₄ , Camilo Jimenez ₅ , Karel Pacak ₄₃ , Christina Pamporaki ₁₄

Affiliation

Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Department of Endocrinology, Cambridge Cancer Centre and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Department of Paediatric Diabetes and Endocrinology, Cambridge Cancer Centre and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Endocrine and Diabetes Service, CHU Sainte-Justine and University of Montreal, Montreal, Québec, Canada.
Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
University Children's Hospital, Department of Paediatric Hematology, Oncology and Stem Cell Transplantation, University of Würzburg, Würzburg, Germany.
Paediatric Oncology Department, Otto von Guericke University Children's Hospital, Magdeburg, Germany.
St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Department of Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.
Department of Diabetes and Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Université de Paris, Paris, France.
Hypertension Unit, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, Paris, France.
Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, Azienda Ospedaliera Universitaria (AOU) Careggi, Florence, Italy.
Division of Endocrinology, Metabolism and Diabetes, First Department of Paediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Unit of Endocrinology, Theagenio Hospital, Thessaloniki, Greece.
Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain.
Princess Maxima Center for Paediatric Oncology, Utrecht, Netherlands.
Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
Department of Public Health and Paediatric Sciences, University of Turin, Turin, Italy.
Division of Hematology/Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
Department of Radiation Oncology, University Hospital of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Department of Paediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK.
Blood and Transplant Research Unit in Organ Donation and Transplantation, National Institute for Health Research, University of Cambridge, Cambridge, UK.
Paediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
U.O.C. Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Istituto di Semeiotica Chirurgica, Università Cattolica del Sacro Cuore, Rome, Italy.
Service de médecine nucléaire, Inserm U970, Sorbonne université, Groupe hospitalier Pitié-Salpétrière, Paris, France.
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR GOSH Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti, Turin, Italy.
Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, Netherlands.
Clinical Child and Adolescent Psychology, Institute of Clinical Psychology and Psychotherapy, Department of Psychology, TU Dresden, Dresden, Germany.
Université Paris Cité, PARCC, INSERM, Paris, France.
Service de Génétique, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Centre for Endocrinology, Barts and the London School of Medicine, London, UK.
ENETS Centre of Excellence, Royal Free Hospital, London, UK.
Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA.

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

中文翻译：

关于儿童和青少年嗜铬细胞瘤和副神经节瘤诊断和管理的国际共识声明

嗜铬细胞瘤和副神经节瘤（PPGL）是罕见的神经内分泌肿瘤，不仅出现在成年期，也出现在儿童期和青少年期。高达 70-80% 的儿童 PPGL 是遗传性的，导致儿科患者转移性和/或多灶性 PPGL 的发生率高于成人患者。与成人患者相比，儿科在肿瘤生物学和管理方面的主要差异，以及罕见病的发病率和治疗挑战，需要密切的专家跨学科团队合作。理想情况下，团队应包括成人和儿童内分泌学家、肿瘤学家、心脏病专家、外科医生、遗传学家、病理学家、放射科医生、临床心理学家和核医学医师。提供国际共识声明应改善患有这些肿瘤的儿童和青少年的护理和结局。

更新日期：2024-08-15

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