The genus Diospyros has gained significant attention in the scientific community owing to its diverse bioactivities ascribed to specific bioactive constituents present in different species of this plant. Phytochemicals like flavonoids, terpenoids, and xanthones have been reported to be present in other Diospyros species responsible for their pharmacological properties. These compounds are well known for their diverse potent therapeutic potentials, such as antimicrobial, antioxidant, anti‐inflammatory, and anticancer properties. This review enlightens the details of the Genus Diospyros, ranging from an overview of its species to an in‐depth analysis of phytochemistry, ethnopharmacology, and their potential as anticancer agents. Different species, including Diospyros lotus, Diospyros kaki, Diospyros maritima, Diospyros mespiliformis, and Diospyros tricolor, presented with an enormous range of anticancer activities against human cancer cell cultures. Moreover, this review highlights the results of various in vitro (antiproliferative, cytotoxic effects against), in vivo (inhibition of tumor, apoptosis), and in silico (GLU234, GLU278, and LYS158 protein residues) studies, elucidating its preclinical anticancer potential. The anticancer potential displays inhibition of cellular proliferation, induction of apoptosis, and mitigation of angiogenesis. Furthermore, this review may elaborate the use of traditional knowledge, modern research, and potential therapeutic applications in the field of anticancer ethnopharmacology. As the modern‐day research approaches novel alternatives to combat diseases like cancer, the Genus Diospyros may emerge as a promising avenue with the potential to yield innovative and effective therapeutic agents.

中文翻译：

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Diospyros 属的抗癌治疗潜力：从植物化学到临床应用——综述


Diospyros 属因其多样化的生物活性而在科学界引起了极大的关注，这归因于该植物不同物种中存在的特定生物活性成分。据报道，类黄酮、萜类化合物和氧杂蒽酮等植物化学物质存在于其他负责其药理特性的 Diospyros 物种中。这些化合物以其多种有效的治疗潜力而闻名，例如抗菌、抗氧化、抗炎和抗癌特性。这篇综述阐明了 Diospyros 属的细节，从其物种的概述到对植物化学、民族药理学及其作为抗癌剂的潜力的深入分析。不同的物种，包括 Diospyros lotus、Diospyros kaki、Diospyros maritima、Diospyros mespiliformis 和 Diospyros tricolor，对人类癌细胞培养物具有广泛的抗癌活性。此外，本综述重点介绍了各种体外 （抗增殖、细胞毒性作用）、体内 （抑制肿瘤、细胞凋亡） 和计算机 （GLU234、GLU278 和 LYS158 蛋白残基） 研究的结果，阐明了其临床前抗癌潜力。抗癌潜力显示抑制细胞增殖、诱导细胞凋亡和减轻血管生成。此外，本综述可能会详细说明传统知识、现代研究和潜在治疗应用在抗癌民族药理学领域的使用。随着现代研究寻求对抗癌症等疾病的新型替代品，Diospyros 属可能会成为一条有前途的途径，有可能产生创新和有效的治疗剂。