The genus Diospyros has gained significant attention in the scientific community owing to its diverse bioactivities ascribed to specific bioactive constituents present in different species of this plant. Phytochemicals like flavonoids, terpenoids, and xanthones have been reported to be present in other Diospyros species responsible for their pharmacological properties. These compounds are well known for their diverse potent therapeutic potentials, such as antimicrobial, antioxidant, anti‐inflammatory, and anticancer properties. This review enlightens the details of the Genus Diospyros, ranging from an overview of its species to an in‐depth analysis of phytochemistry, ethnopharmacology, and their potential as anticancer agents. Different species, including Diospyros lotus, Diospyros kaki, Diospyros maritima, Diospyros mespiliformis, and Diospyros tricolor, presented with an enormous range of anticancer activities against human cancer cell cultures. Moreover, this review highlights the results of various in vitro (antiproliferative, cytotoxic effects against), in vivo (inhibition of tumor, apoptosis), and in silico (GLU234, GLU278, and LYS158 protein residues) studies, elucidating its preclinical anticancer potential. The anticancer potential displays inhibition of cellular proliferation, induction of apoptosis, and mitigation of angiogenesis. Furthermore, this review may elaborate the use of traditional knowledge, modern research, and potential therapeutic applications in the field of anticancer ethnopharmacology. As the modern‐day research approaches novel alternatives to combat diseases like cancer, the Genus Diospyros may emerge as a promising avenue with the potential to yield innovative and effective therapeutic agents.

中文翻译：

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柿属的抗癌治疗潜力：从植物化学到临床应用——综述


属柿属由于该植物不同物种中存在的特定生物活性成分具有多种生物活性，因此受到科学界的广泛关注。据报道，黄酮类化合物、萜类化合物和氧杂蒽酮等植物化学物质也存在于其他物质中。柿属物种对其药理特性负责。这些化合物以其多种有效的治疗潜力而闻名，例如抗菌、抗氧化、抗炎和抗癌特性。这篇综述揭示了柿树属的详细信息，从物种概述到植物化学、民族药理学及其作为抗癌剂的潜力的深入分析。不同的物种，包括黑枣,柿子,海柿,黑枣， 和三色柿，对人类癌细胞培养物具有广泛的抗癌活性。此外，本综述强调了各种体外（抗增殖、细胞毒性作用）、体内（抑制肿瘤、细胞凋亡）和计算机模拟（GLU234、GLU278 和 LYS158 蛋白质残基）研究，阐明了其临床前抗癌潜力。抗癌潜力表现出抑制细胞增殖、诱导细胞凋亡和减轻血管生成。此外，这篇综述可能会详细阐述传统知识、现代研究的使用以及抗癌民族药理学领域的潜在治疗应用。 随着现代研究寻找对抗癌症等疾病的新替代品，柿属可能成为一条有前途的途径，有可能产生创新和有效的治疗药物。