Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4,Molecular Nutrition & Food Research

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Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-13 , DOI: 10.1002/mnfr.202400013
Jianan Cheng ₁ , Lothar Rink ₁ , Inga Wessels ₁

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Neutrophils play a decisive role during the immediate defense against infections. However, as observed during rheumatoid arthritis, activated neutrophils can also cause tissue damage. Previous studies indicate that zinc supplementation may alter certain neutrophil functions. However, precise underlying mechanisms and possible effects of zinc deficiency remain incompletely understood. The objective of this study is to investigate the effects of changes in zinc status on formation of neutrophil extracellular traps (NETs) and other fundamental neutrophil functions.

中文翻译：

锌补充剂通过降低肽基精氨酸脱亚胺酶 4 的表达来减少中性粒细胞细胞外陷阱的形成

中性粒细胞在直接防御感染过程中起着决定性的作用。然而，正如在类风湿性关节炎期间观察到的那样，活化的中性粒细胞也会导致组织损伤。先前的研究表明，锌补充剂可能会改变某些中性粒细胞功能。然而，锌缺乏症的确切潜在机制和可能影响仍不完全清楚。本研究的目的是研究锌状态变化对中性粒细胞胞外陷阱（NET）形成和其他基本中性粒细胞功能的影响。

更新日期：2024-08-13

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