Human skin is the host to various commensal microbes that constitute a substantial microbial community. The reciprocal communication between these microbial inhabitants and host cells upholds both the morphological and functional attributes of the skin layers, contributing indispensably to microenvironmental and tissue homeostasis. Thus, disruption of the skin barrier or imbalances in the microbial communities can exert profound effects on the behavior of host cells. This influence, mediated by the microbes themselves or their metabolites, manifests in diverse outcomes. In this review, we examine existing knowledge to provide insight into the nuanced behavior exhibited by the microbiota on skin cells in health and disease states. These interactions provide insight into potential cellular targets for future microbiota-based therapies to prevent and treat skin disease.

中文翻译：

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疾病中皮肤细胞的共生微生物调控


人类皮肤是构成大量微生物群落的各种共生微生物的宿主。这些微生物居民和宿主细胞之间的相互交流维护了皮肤层的形态和功能属性，对微环境和组织稳态不可或缺地做出了贡献。因此，皮肤屏障的破坏或微生物群落的失衡会对宿主细胞的行为产生深远的影响。这种由微生物本身或其代谢物介导的影响表现为不同的结果。在这篇综述中，我们检查了现有知识，以深入了解微生物群在健康和疾病状态下对皮肤细胞表现出的细微行为。这些相互作用为未来基于微生物群的疗法预防和治疗皮肤病的潜在细胞靶点提供了见解。