Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome,Cell Host & Microbe

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Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-08-14 , DOI: 10.1016/j.chom.2024.07.010
Trishla Sinha ₁ , Jelmer R Prins ₂ , Asier Fernández-Pato ₁ , Marloes Kruk ₁ , Thomas Dierikx ₃ , Tim de Meij ₄ , Marjon de Boer ₅ , Jan Freark de Boer ₆ , Sicco Scherjon ₂ , Alexander Kurilshikov ₁ , Alexandra Zhernakova ₁

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Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short-chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.

中文翻译：

剖宫产期间母亲预防性使用抗生素对婴儿肠道微生物群的影响有限

接受剖腹产 (CS) 的孕妇通常在切开皮肤之前接受抗生素治疗以预防感染。为了调查抗生素的使用时机是否影响婴儿肠道微生物组，我们对通过预定 CS 分娩的妇女进行了一项随机对照试验 (NCT06030713)，这些妇女在皮肤切开前或脐带结扎后接受抗生素治疗。我们对 28 名婴儿在出生后 8 个时间点的 172 个样本进行了纵向分析，并对 3 个队列的 79 名婴儿在 1 个月时进行了横断面分析。尽管没有发现与细菌组成、代谢途径、短链脂肪酸和胆汁酸的显着关联，但我们观察到各组之间在菌株水平和抗生素抗性基因负载方面存在细微差异。相反，喂养方式是影响婴儿微生物组成的主要和决定性因素。总之，CS 期间使用抗生素对早期肠道微生物组的影响有限。

更新日期：2024-08-14

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