The cellular composition of fibrous tissue around orthopaedic implants and the genetic pathways involved in its formation are unclear. We find that leptin-receptor-expressing cells activate the adhesion G-protein-coupled receptor F5 (ADGRF5) pathway to form peri-implant fibrous tissue. Inhibition of ADGRF5 in leptin-receptor-expressing cells can prevent and reverse peri-implant fibrosis.

中文翻译：

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种植体周围纤维化的形成和维持需要表达瘦素受体的骨骼细胞


骨科植入物周围纤维组织的细胞组成及其形成所涉及的遗传途径尚不清楚。我们发现表达瘦素受体的细胞激活粘附 G 蛋白偶联受体 F5 （ADGRF5） 通路，形成种植体周围纤维组织。在瘦素受体表达细胞中抑制 ADGRF5 可以预防和逆转种植体周围纤维化。