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Interfacially Self-Assembled Mutifunctional Protein Thin Films for Accelerated Wound Healing
ACS Macro Letters ( IF 5.1 ) Pub Date : 2024-08-12 , DOI: 10.1021/acsmacrolett.4c00416
Yajiao Geng 1 , Juntao Hu 2 , Yuze Gao 1 , Jialiang Guo 1 , Hao Hao 1 , Fengjie Hao 1 , Tiezhu Li 3 , Yihao Chen 3 , Wei Huang 3 , Quan Luo 1, 4
Affiliation  

The design of mutifunctional protein films for large-area spatially ordered arrays of functional components holds great promise in the field of biomedical applications. Herein, interfacial electrostatic self-assembly was employed to construct a large-scale protein thin film by inducing electrostatic interactions between three bovine serum albumin (BSA)-coated nanoclusters and cetyltrimethylammonium bromide (CTAB), leading to their spontaneous organization and uniform distribution at the oil–water interface. This protein film demonstrated excellent multienzyme functions, high antibacterial activity, and pH-responsive drug release capability. Therefore, it can accelerate the wound closure process through a synergistic effect that includes reducing local blood glucose levels, regulating cellular oxidative stress, eradicating bacteria, and promoting cell proliferation.

中文翻译:


用于加速伤口愈合的界面自组装多功能蛋白质薄膜



用于大面积空间有序功能组件阵列的多功能蛋白质膜的设计在生物医学应用领域具有广阔的前景。在此,利用界面静电自组装技术,通过诱导三个牛血清白蛋白(BSA)涂覆的纳米团簇与十六烷基三甲基溴化铵(CTAB)之间的静电相互作用来构建大规模蛋白质薄膜,从而导致它们自发组织并均匀分布在薄膜上。油水界面。该蛋白膜表现出优异的多酶功能、高抗菌活性和pH响应性药物释放能力。因此,它可以通过降低局部血糖水平、调节细胞氧化应激、消灭细菌和促进细胞增殖等协同作用来加速伤口闭合过程。
更新日期:2024-08-12
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