Primate hibernation: The past, present, and promise of captive dwarf lemurs,Annals of the New York Academy of Sciences

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Primate hibernation: The past, present, and promise of captive dwarf lemurs
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2024-08-13 , DOI: 10.1111/nyas.15206
Marina B Blanco _{1,

2} , Lydia K Greene _{1,

2} , Kay H Welser ₂ , Erin E Ehmke ₂ , Anne D Yoder ₁ , Peter H Klopfer ₁

Affiliation

The dwarf lemurs (Cheirogaleus spp.) of Madagascar are the only obligate hibernators among primates. Despite century-old field accounts of seasonal lethargy, and more recent evidence of hibernation in the western fat-tailed dwarf lemur (Cheirogaleus medius), inducing hibernation in captivity remained elusive for decades. This included the Duke Lemur Center (DLC), which maintains fat-tailed dwarf lemurs and has produced sporadic research on reproduction and metabolism. With cumulative knowledge from the field, a newly robust colony, and better infrastructure, we recently induced hibernation in DLC dwarf lemurs. We describe two follow-up experiments in subsequent years. First, we show that dwarf lemurs under stable cold conditions (13°C) with available food continued to eat daily, expressed shallower and shorter torpor bouts, and had a modified gut microbiome compared to peers without food. Second, we demonstrate that dwarf lemurs under fluctuating temperatures (12–30°C) can passively rewarm daily, which was associated with altered patterns of fat depletion and reduced oxidative stress. Despite the limitations of working with endangered primates, we highlight the promise of studying hibernation in captive dwarf lemurs. Follow-up studies on genomics and epigenetics, metabolism, and endocrinology could have relevance across multidisciplinary fields, from biomedicine to evolutionary biology, and conservation.

中文翻译：

灵长类动物冬眠：圈养侏儒狐猴的过去、现在和未来

马达加斯加的侏儒狐猴（Cheirogaleus spp.）是灵长类动物中唯一的专性冬眠者。尽管一个世纪前的田野记录表明了季节性嗜睡，并且最近有证据表明西部肥尾侏儒狐猴（Cheirogaleus medius）冬眠，但在圈养中诱导冬眠几十年来仍然难以捉摸。这包括杜克狐猴中心（DLC），该中心维护着肥尾侏儒狐猴，并对繁殖和新陈代谢进行了零星的研究。凭借该领域积累的知识、新近健壮的蚁群和更好的基础设施，我们最近诱导了 DLC 侏儒狐猴的冬眠。我们描述了随后几年的两次后续实验。首先，我们表明，与没有食物的同龄人相比，侏儒狐猴在稳定的寒冷条件（13°C）下继续每天进食，表现出更浅和更短的麻痹发作，并且肠道微生物组发生了变化。其次，我们证明侏儒狐猴在波动温度（12-30°C）下可以每天被动复温，这与脂肪消耗模式的改变和氧化应激的减少有关。尽管与濒危灵长类动物合作存在局限性，但我们强调了研究圈养侏儒狐猴冬眠的前景。关于基因组学和表观遗传学、代谢和内分泌学的后续研究可能与多学科领域相关，从生物医学到进化生物学和保护。

更新日期：2024-08-13

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