Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults,Alzheimer's & Dementia

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Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-08-13 , DOI: 10.1002/alz.14051
Maria Misiura _{1,

2} , Chinkuli Munkombwe ₃ , Kay Igwe ₄ , Danielle D Verble ₅ , Kelly D S Likos ₅ , Lex Minto ₁ , Alexandria Bartlett ₁ , Henrik Zetterberg _{6,

7,

8,

9,

10,

11} , Jessica A Turner ₁₂ , Vonetta M Dotson _{1,

13} , Adam M Brickman _{4,

14} , William T Hu ₁₅ , Whitney Wharton ₅

Affiliation

Department of Psychology, Georgia State University, Atlanta, Georgia, USA.
Tri-Institutional Center for Translational Research in Neuroimaging & Data Science, Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia, USA.
Neuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.
The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Mölndal and Gothenburg, University of Gothenburg, Gothenburg, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, UCL Queen Square Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, Maple House, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Department of Psychiatry and Mental Health, College of Medicine, Ohio State University, Columbus, Ohio, USA.
Gerontology Department, Georgia State University, Atlanta, Georgia, USA.
Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Institute for Health, Health Care Policy, and Aging Research, Rutgers University, New Brunswick, New Jersey, USA.

In this study, we investigated biomarkers in a midlife, racially diverse, at-risk cohort to facilitate early identification and intervention. We examined neuroimaging measures, including resting state functional magnetic resonance imaging (fMRI), white matter hyperintensity vo (WMH), and hippocampal volumes, alongside cerebrospinal fluid (CSF) markers.

中文翻译：

神经影像学与种族多样化的中年高危人群中阿尔茨海默病生物标志物浓度的相关性

在这项研究中，我们调查了中年、种族多样化、高危队列中的生物标志物，以促进早期识别和干预。我们检查了神经影像学措施，包括静息态功能磁共振成像（fMRI）、白质高信号 vo （WMH）和海马体积，以及脑脊液（CSF）标志物。

更新日期：2024-08-13

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