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Testing whether the relations between sex and psychopathology are accounted for by structural morphometry in ABCD.
Journal of Psychopathology and Clinical Science ( IF 3.1 ) Pub Date : 2024-03-14 , DOI: 10.1037/abn0000892
Leigha Rose 1 , Benjamin Listyg 1 , Max M Owens 2 , Courtland S Hyatt 3 , Nathan T Carter 4 , Dorothy R Carter 4 , Donald R Lynam 5 , Joshua D Miller 1
Affiliation  

Sex differences in psychopathology are well-established, with females demonstrating higher rates of internalizing (INT) psychopathology and males demonstrating higher rates of externalizing (EXT) psychopathology. Using two waves of data from the Adolescent Brain Cognitive Development Study (N = 6,778 at each wave), the current study tested whether the relations between sex and psychopathology might be accounted for by structural brain differences. In general, we found robust, relatively consistent relations between sex and structural morphometry across waves. Relatively few morphometric brain variables were significantly related to INT or EXT across waves, however, with very small effect sizes when present. Next, we tested the extent to which each morphometric brain variable could account for the associations of sex with INT and EXT psychopathology. We found a total of 26 brain regions that accounted for significant portions of the associations between sex and psychopathology across both waves (almost all related to EXT), although the effects present were very small. The current evidence suggests that in children aged 9-12, multiple whole-brain and regional brain variables appear to statistically account for small portions of the sex-psychopathology links, especially for externalizing. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译:


测试 ABCD 中的结构形态计量学是否可以解释性别与精神病理学之间的关系。



精神病理学中的性别差异是明确的,女性表现出更高的内化(INT)精神病理学比率,而男性表现出更高的外化(EXT)精神病理学比率。当前的研究利用青少年大脑认知发展研究的两波数据(每波 N = 6,778)测试了性别与精神病理学之间的关系是否可以通过大脑结构差异来解释。总的来说,我们发现跨波的性别和结构形态测量之间存在稳健、相对一致的关系。然而,相对较少的形态测量大脑变量与跨波的 INT 或 EXT 显着相关,但当存在时,其影响大小非常小。接下来,我们测试了每个形态测量大脑变量在多大程度上可以解释性别与 INT 和 EXT 精神病理学之间的关联。我们发现总共 26 个大脑区域在两个波中对性别与精神病理学之间的关联(几乎都与 EXT 相关)起着重要作用,尽管存在的影响非常小。目前的证据表明,在 9-12 岁的儿童中,多个全脑和区域脑变量似乎在统计上解释了一小部分性别与心理病理学联系,尤其是外化方面。 (PsycInfo 数据库记录 (c) 2024 APA,保留所有权利)。
更新日期:2024-03-14
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