The currently available anti-cancer therapies, such as gamma-radiation and chemotherapeutic agents, induce cell death and cellular senescence not only in cancer cells but also in the adjacent normal tissue. New anti-tumor approaches focus on limiting the side effects on normal cells. In this frame, the potential anti-tumor properties of Pulsed Electromagnetic Fields (PEMFs) through the irradiation of breast cancer epithelial cells (MCF-7 and MDA-MB-231) and normal fibroblasts (FF95) were investigated. PEMFs had a frequency of 8 Hz, full-square wave type and magnetic flux density of 0.011 T and were applied twice daily for 5 days. The data collected showcase that PEMF application decreases the proliferation rate and viability of breast cancer cells while having the opposite effect on normal fibroblasts. Moreover, PEMF irradiation induces cell death and cellular senescence only in breast cancer cells without any effect in the non-cancerous cells. These findings suggest PEMF irradiation as a novel, non-invasive anti-cancer strategy that, when combined with senolytic drugs, may eliminate both cancer and the remaining senescent cells, while simultaneously avoiding the side effects of the current treatments.

中文翻译：

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脉冲电磁场​​ (PEMF) 触发癌细胞死亡和衰老。


目前可用的抗癌疗法，例如伽马射线和化疗药物，不仅在癌细胞中而且在邻近的正常组织中诱导细胞死亡和细胞衰老。新的抗肿瘤方法侧重于限制对正常细胞的副作用。在此框架中，研究了脉冲电磁场​​ (PEMF) 通过照射乳腺癌上皮细胞（MCF-7 和 MDA-MB-231）和正常成纤维细胞（FF95）的潜在抗肿瘤特性。 PEMF 的频率为 8 Hz，全方波型，磁通密度为 0.011 T，每天施加两次，持续 5 天。收集的数据表明，PEMF 应用降低了乳腺癌细胞的增殖率和活力，同时对正常成纤维细胞产生相反的影响。此外，PEMF 辐射仅在乳腺癌细胞中诱导细胞死亡和细胞衰老，对非癌细胞没有任何影响。这些发现表明，PEMF 照射是一种新型的非侵入性抗癌策略，与衰老药物结合使用时，可以消除癌症和剩余的衰老细胞，同时避免当前治疗的副作用。