Response to immune checkpoint blockade is increased in obesity-related cancers, but the mechanisms remain unclear. In a recent issue of Nature, Bader et al. report that obesity in mice induces macrophage PD-1 upregulation to promote tumor growth while potentiating immunotherapy responses.

中文翻译：

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巨噬细胞深入研究癌症中的肥胖悖论

肥胖相关癌症对免疫检查点阻断的反应增加，但其机制仍不清楚。在最近一期的《自然》杂志上，Bader 等人。报道称，小鼠肥胖会诱导巨噬细胞 PD-1 上调，促进肿瘤生长，同时增强免疫治疗反应。