Persistent symptoms are common in the general population and even more so in people with hypothyroidism. When symptoms are unexplained and brought to medical attention, they can be referred to as medically not yet explained symptoms (MNYES), a term preferred to other descriptors by patients, care-givers and experts. MNYES might be neglected by endocrinologists or misattributed to hypothyroidism. Awareness of MNYES could open up more effective and less harmful interventions for patients who present to endocrinologists with unexplained symptoms than costly over-investigations and over-treatment with thyroid hormones (such as levothyroxine and liothyronine). The role of the endocrinologist is to recognize and acknowledge that MNYES could be underlying a patient’s presentation, to communicate effectively with the patient and others involved in the patient’s care, to apply a ‘two-track approach’ in management by paying equal attention to physical and psychosocial contributors, and to collaborate with other relevant health professionals. Categorization of patients into levels of risk for symptom deterioration helps in selecting suitable therapies. Effective management of MNYES demands time, training, expertise and resources.

持续症状在普通人群中很常见，在甲状腺功能减退症患者中更是如此。当症状无法解释并就医时，它们可以被称为医学上尚未解释的症状 （MNYES），患者、护理人员和专家更喜欢使用这个术语而不是其他描述符。MNYES 可能被内分泌学家忽视或被误认为是甲状腺功能减退症。与昂贵的甲状腺激素（如左旋甲状腺素和碘塞罗宁）过度检查和过度治疗相比，对 MNYES 的认识可以为因不明原因症状而就诊的内分泌学家提供更有效、危害更小的干预措施。内分泌科医生的作用是认识到并承认 MNYES 可能是患者表现的基础，与患者和参与患者护理的其他人进行有效沟通，通过同等关注身体和社会心理贡献者在管理中应用“双轨方法”，并与其他相关卫生专业人员合作。将患者分类为症状恶化的风险级别有助于选择合适的治疗方法。MNYES 的有效管理需要时间、培训、专业知识和资源。