Tissue-resident stem cells are essential for development and repair, and in the skeleton, this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells. Recent studies have utilized techniques such as fluorescence-activated cell sorting, lineage tracing, and single-cell sequencing to investigate the involvement of SSCs in bone development, homeostasis, and disease. These investigations have allowed researchers to map the lineage commitment trajectory of SSCs in different parts of the body and at different time points. Furthermore, recent studies have shed light on the characteristics of SSCs in both physiological and pathological conditions. This review focuses on discussing the spatiotemporal distribution of SSCs and enhancing our understanding of the diversity and plasticity of SSCs by summarizing recent discoveries.

中文翻译：

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骨骼干细胞在骨骼发育、体内平衡和疾病中的作用。


组织驻留干细胞对于发育和修复至关重要，在骨骼中，这一功能是由最近发现的骨骼干细胞（SSC）实现的。然而，最近的研究发现，SSC 并不是整体的，长骨、颅面部位和脊柱都是由不同的干细胞形成的。最近的研究利用荧光激活细胞分选、谱系追踪和单细胞测序等技术来研究 SSC 在骨骼发育、体内平衡和疾病中的参与。这些研究使研究人员能够绘制出 SSC 在身体不同部位和不同时间点的谱系定型轨迹。此外，最近的研究揭示了SSC在生理和病理条件下的特征。本综述重点讨论SSCs的时空分布，并通过总结最近的发现来增强我们对SSCs多样性和可塑性的理解。