Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism. This review discusses the mechanisms of metabolic cell death-ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis-and explores their potential in cancer therapy. Our review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.

中文翻译：

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癌症中的代谢性细胞死亡：铁死亡、铜死亡、二硫死亡等。


细胞死亡抵抗是癌症的一个标志。最近的研究已确定代谢性细胞死亡是由于细胞代谢不平衡而导致的受调节细胞死亡的独特形式。本综述讨论了代谢性细胞死亡（铁死亡、铜死亡、二硫死亡、溶菌素死亡和碱死亡）的机制，并探讨了它们在癌症治疗中的潜力。我们的综述强调了代谢细胞死亡途径的复杂性，并为癌症治疗的创新治疗途径提供了见解。