Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606,Alzheimer's & Dementia

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Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-08-12 , DOI: 10.1002/alz.14086
Jose A Godoy-Lugo ₁ , Max A Thorwald ₁ , Mafalda Cacciottolo _{1,

2} , Carla D'Agostino ₁ , Ararat Chakhoyan _{3,

4} , Constantinos Sioutas ₅ , Rudolph E Tanzi _{6,

7} , Kevin D Rynearson ₈ , Caleb E Finch _{1,

9}

Affiliation

Chronic air pollution (AirPoll) is associated with accelerated cognitive decline and risk of Alzheimer's disease (AD). Correspondingly, wild-type and AD-transgenic rodents exposed to AirPoll have increased amyloid peptides and behavioral impairments.

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