Effective and less toxic therapies for medulloblastoma have proved to be highly elusive. In this issue of Cancer Cell, Yang et al. show that thyroid hormone treatment leads to the activation of neurogenic differentiation factor 1 (NeuroD1) and differentiation of medulloblastoma cells through reversing EZH2-mediated transcriptional repression of NeuroD1.

中文翻译：

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导致髓母细胞瘤分化结束

事实证明，针对髓母细胞瘤的有效且毒性较小的疗法非常难以捉摸。在本期《癌细胞》中，杨等人。研究表明，甲状腺激素治疗可通过逆转 EZH2 介导的 NeuroD1 转录抑制，激活神经源性分化因子 1 (NeuroD1) 并促进髓母细胞瘤细胞分化。