A New Process To Prepare 1-(4-Chlorobenzyl)-1H-imidazole-4,5-dicarboxamide, a Potential Anticoccidial Agent,Organic Process Research & Development

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A New Process To Prepare 1-(4-Chlorobenzyl)-1H-imidazole-4,5-dicarboxamide, a Potential Anticoccidial Agent
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2024-08-09 , DOI: 10.1021/acs.oprd.4c00278
Daniel P. Walker ₁ , Ronald J. VanderRoest ₁ , Tapan Maji ₂ , Shankar Ramanathan ₂ , Matthew J. Birchmeier ₁ , Michelle Y. Johnson ₁ , Calin D. Sferdean ₁ , Randall L. DeJong ₁ , Thomas Geurden ₃

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Anticoccidials are an important class of compounds for treating parasitic diseases of a wide variety of animals, especially poultry. 1-(4-Chlorobenzyl)-1H-imidazole-4,5-dicarboxamide (1) has been reported in the patent literature to possess potent anticoccidial activity. In view of the earlier published synthetic process, which relies on expensive imidazole-4,5-dicarboxylic acid (IDA) as a starting material, a potentially more cost-effective process to prepare 1 from diaminomaleonitrile (DAMN) was developed. This article describes the development details for each of the three steps involved in the new process.

中文翻译：

制备潜在抗球虫剂 1-(4-氯苄基)-1H-咪唑-4,5-二甲酰胺的新工艺

抗球虫药是一类重要的化合物，用于治疗多种动物尤其是家禽的寄生虫病。专利文献已报道1-(4-氯苄基)-1H-咪唑-4,5-二甲酰胺( 1 )具有有效的抗球虫活性。鉴于早期公布的合成工艺依赖于昂贵的咪唑-4,5-二甲酸（IDA）作为起始原料，开发了一种可能更具成本效益的从二氨基顺丁烯二腈（DAMN）制备1的工艺。本文描述了新流程中涉及的三个步骤中每个步骤的开发细节。

更新日期：2024-08-09

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