UV-A radiation contributes to photoaging/photocarcinogenesis by generating inflammation and oxidative damage. Current photoprotective strategies are limited by the availability/utilization of UV-A filters, highlighting an unmet need. Cannabidiol (CBD), having anti-inflammatory/antioxidant properties via regulation of nuclear erythroid 2–related factor, heme oxygenase 1, and peroxisome proliferator-activated receptor gamma, could potentially mitigate damage from UV-A exposure.

中文翻译：

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局部纳米胶囊大麻二酚乳膏作为对抗 UV-A 诱导的核和线粒体 DNA 损伤的创新策略：一项试点随机临床研究


UV-A 辐射通过产生炎症和氧化损伤来促进光老化/光致癌。目前的光保护策略受到 UV-A 过滤器的可用性/利用率的限制，凸显了未满足的需求。大麻二酚 （CBD） 通过调节核红细胞 2 相关因子、血红素加氧酶 1 和过氧化物酶体增殖物激活受体 γ 具有抗炎/抗氧化特性，可能会减轻 UV-A 暴露造成的损害。