An efficient one-pot approach to access functionalized 3,4-dihydro-[1,3]oxazin-2-one skeletons has been developed through BF·EtO-mediated addition-cyclization of ynamides and Boc phenylsulfones. The metal-free catalytic method exhibits good functional group compatibility. This study provides a practical new method for the synthesis of oxazinone skeletons.

中文翻译：

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BF3·Et2O介导的N-Boc苯磺酰基与炔酰胺一锅合成3,4-二氢-[1,3]恶嗪-2-酮类化合物


通过 BF·EtO 介导的 ynamides 和 Boc 苯砜的加成环化，开发了一种有效的一锅法来获得功能化的 3,4-二氢-[1,3]oxazin-2-one 骨架。无金属催化方法表现出良好的官能团兼容性。该研究为恶嗪酮骨架的合成提供了一种实用的新方法。