Inflammatory response after prehospital high-dose glucocorticoid to patients resuscitated from out-of-hospital cardiac arrest: A sub-study of the STEROHCA trial,Resuscitation

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Inflammatory response after prehospital high-dose glucocorticoid to patients resuscitated from out-of-hospital cardiac arrest: A sub-study of the STEROHCA trial
Resuscitation ( IF 6.5 ) Pub Date : 2024-07-31 , DOI: 10.1016/j.resuscitation.2024.110340
Laust E R Obling ₁ , Rasmus P Beske ₁ , Martin A S Meyer ₁ , Johannes Grand ₁ , Sebastian Wiberg ₂ , Anders Damm-Hejmdal ₃ , Mette Bjerre ₄ , Ruth Frikke-Schmidt ₅ , Fredrik Folke ₆ , Jacob E Møller ₇ , Jesper Kjaergaard ₈ , Christian Hassager ₈

Affiliation

Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark.
Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiothoracic Anesthesiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine - University of Copenhagen, Copenhagen, Denmark.
Emergency Medical Services - Capital Region of Denmark, Copenhagen, Denmark.
Department of Clinical Medicine, Medical/Steno Aarhus Research Laboratory - Aarhus University, Aarhus, Denmark.
Department of Clinical Medicine - University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark.
Department of Clinical Medicine - University of Copenhagen, Copenhagen, Denmark; Emergency Medical Services - Capital Region of Denmark, Copenhagen, Denmark; Department of Cardiology, Herlev-Gentofte Hospital - Copenhagen University Hospital, Copenhagen, Denmark.
Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine - University of Copenhagen, Copenhagen, Denmark; Department of Cardiology - Odense University Hospital, Odense, Denmark.
Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine - University of Copenhagen, Copenhagen, Denmark.

The post-cardiac arrest syndrome (PCAS) after out-of-hospital cardiac arrest (OHCA) is characterized by a series of pathological events, including inflammation. In the randomized “STERoid for OHCA” (STEROHCA) trial, prehospital high-dose glucocorticoid decreased interleukin (IL) 6 and C-reactive protein levels following resuscitated OHCA. The aim of this predefined sub-study was to assess the inflammatory response the first three days of admission.

中文翻译：

院外心脏骤停复苏患者院前大剂量糖皮质激素后的炎症反应：STEROHCA 试验的亚研究

院外心脏骤停后综合征（PCAS）后心脏骤停综合征（PCAS）的特征是一系列病理事件，包括炎症。在随机“STERoid for OHCA”（STEROHCA）试验中，院前大剂量糖皮质激素在复苏 OHCA 后降低了白细胞介素（IL） 6 和 C 反应蛋白水平。这项预定义的子研究的目的是评估入院前三天的炎症反应。

更新日期：2024-07-31

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