Measles in persons with secondary vaccination failure (SVF) may be less infectious than cases in unvaccinated persons. Our systematic review aimed to assess transmission risk for measles after SVF. We searched PubMed, Embase, and Web of Science databases from their inception dates. Inclusion criteria were articles describing persons who were exposed to measles-infected persons who had experienced SVF. Across the included 14 studies, >3,030 persons were exposed to measles virus from SVF cases, of whom 180 were susceptible, indicating secondary attack rates of 0%–6.25%. We identified 109 cases of SVF from the studies; 10.09% (n = 11) of case-patients transmitted the virus, resulting in 23 further cases and yielding an effective reproduction number of 0.063 (95% CI 0.0–0.5). These findings suggest a remarkably low attack rate for SVF measles cases, suggesting that, In outbreak situations, public health management of unvaccinated persons could be prioritized over persons with SVF.

继发性疫苗接种失败 （SVF） 患者的麻疹传染性可能低于未接种疫苗者的病例。我们的系统评价旨在评估 SVF 后麻疹的传播风险。我们检索了 PubMed、Embase 和 Web of Science 数据库，从建库日期开始。纳入标准是描述暴露于经历过 SVF 的麻疹感染者的人的文章。在纳入的 14 项研究中，>3,030 人从 SVF 病例中暴露于麻疹病毒，其中 180 人易感，表明继发率为 0%-6.25%。我们从研究中确定了 109 例 SVF;10.09% （n = 11） 的病例患者传播了病毒，导致另外 23 例病例，有效繁殖数为 0.063 （95% CI 0.0-0.5）。这些发现表明 SVF 麻疹病例的发病率非常低，这表明，在疫情爆发情况下，对未接种疫苗者的公共卫生管理可以优先于 SVF 患者。