It is unknown how the Addictions Neuroclinical Assessment markers—negative affect, sensation seeking, and executive function—contribute to substance use development. This study examined whether associations of negative affect and sensation seeking with substance use vary by executive function. Participants were 167 adolescents (47% female) who participated annually for four years (M_age = 14.07, SD_age = 0.54 at Time 1). There were within-person bidirectional associations between higher negative affect and higher substance use for adolescents with lower executive function. Adolescents with higher sensation seeking at age 14 exhibited increasing substance use trajectories from age 14 to 17, regardless of executive function level. Negative affect and substance use influence each other within individuals, whereas sensation seeking predicts substance use between individuals.

目前尚不清楚成瘾神经临床评估标志物——负面影响、感觉寻求和执行功能——如何促进物质使用的发展。本研究检查了负面影响和感觉寻求与物质使用的关联是否因执行功能而异。参与者是 167 名青少年 （47% 为女性），他们每年参加四年 （M_年龄 = 14.07，SD _年龄 = 0.54 在时间 1）。对于执行功能较低的青少年，较高的负面影响和较高的物质使用之间存在人体内双向关联。无论执行功能水平如何，在 14 岁时寻求感觉较高的青少年在 14 至 17 岁期间表现出增加的物质使用轨迹。负面影响和物质使用在个体内部相互影响，而寻求感觉则预测个体之间的物质使用。