(+)-Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways,Molecular Nutrition & Food Research

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(+)-Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-09 , DOI: 10.1002/mnfr.202400387
Ying Ni _{1,

2,

3} , Dina Zhu _{1,

2,

3} , Chao Chen _{1,

2,

3} , Fan Wang _{1,

2,

3} , Yanyan Miu _{1,

2,

3} , Wensheng Zhang _{1,

2,

3}

Affiliation

Diabetic nephropathy (DN), a complication of diabetes mellitus, is becoming a significant global health concern, with no complete cure currently available. Tea is regarded as an essential component of a balanced diet and contains (+)-Catechin (CE), which exert a range of pharmacological effects. Consequently, CE may be a potential treatment for DN. The objective of this study is to examine the protective effects and underlying mechanisms of CE on DN, with a particular focus on the epithelial-mesenchymal transition (EMT) process, which plays a pivotal role in regulating DN.

中文翻译：

（+）-儿茶素通过多种途径缓解 EMT 在糖尿病肾病中发挥保护作用

糖尿病肾病（DN）是糖尿病的一种并发症，正在成为一个重要的全球健康问题，目前尚无完全治愈的方法。茶被认为是均衡饮食的重要组成部分，含有（+）-儿茶素（CE），可发挥一系列药理作用。因此，CE 可能是 DN 的潜在治疗方法。本研究的目的是检查 CE 对 DN 的保护作用和潜在机制，特别关注上皮-间充质转化（EMT）过程，该过程在调节 DN 中起关键作用。

更新日期：2024-08-09

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