OBJECTIVE Sleep and circadian disturbance is highly comorbid with a range of psychological disorders, especially major depressive disorder (MDD). In view of the complexity of sleep and circadian problems in MDD, this study aimed to evaluate the efficacy of a group-based transdiagnostic intervention for sleep and circadian dysfunction (TranS-C) for improving depressive symptoms and sleep and circadian functions. METHOD One hundred fifty-two adults diagnosed with comorbid MDD and sleep and circadian dysfunctions were randomized into TranS-C group treatment (TranS-C; n = 77) or care as usual (CAU; n = 75) control group. The TranS-C group received six weekly 2-hr group sessions of TranS-C, whereas the CAU group continued to receive usual care. Assessments were at baseline, immediate (Week 7), and 12-week (Week 19) posttreatment. Primary and secondary outcomes included depression, anxiety, sleep disturbances, fatigue, quality of life, and functional impairment. RESULTS The TranS-C group showed significant improvement in depressive symptoms (p < .001, d = 0.84), insomnia severity (p < .001, d = 0.77), sleep disturbances (p < .001, d = 1.15), sleep-related impairment (p < .001, d = 1.22), fatigue (p < .001, d = 1.06), anxiety symptoms (p = .004, d = 0.67), quality of life (p < .001, d = 0.71), and sleep diary-derived parameters (ps < .05, d = 0.12-0.77) relative to the CAU group at immediate posttreatment. These treatment gains remained significant at 12-week follow-up. Significant improvement in functional impairment was also noted at 12-week follow-up. CONCLUSIONS TranS-C was efficacious and acceptable in alleviating depressive symptoms and sleep and circadian disruptions in adults with MDD. The group format appears to be a low-cost, widely disseminable option to deliver TranS-C. Further research on TranS-C to examine its benefits on other psychiatric disorders is warranted. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

中文翻译：

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针对重度抑郁症的基于团体的跨诊断睡眠和昼夜节律治疗：一项随机对照试验。


目的 睡眠和昼夜节律紊乱与一系列心理疾病，尤其是重度抑郁症 (MDD) 高度共存。鉴于MDD睡眠和昼夜节律问题的复杂性，本研究旨在评估基于群体的睡眠和昼夜节律功能障碍跨诊断干预（TranS-C）对于改善抑郁症状以及睡眠和昼夜节律功能的疗效。方法 152 名诊断患有共病 MDD 以及睡眠和昼夜节律功能障碍的成年人被随机分为 TranS-C 治疗组 (TranS-C; n = 77) 或照常护理 (CAU; n = 75) 对照组。 TranS-C 组每周接受六次每次 2 小时的 TranS-C 小组治疗，而 CAU 组继续接受常规护理。评估在基线、治疗后即刻（第 7 周）和治疗后 12 周（第 19 周）进行。主要和次要结局包括抑郁、焦虑、睡眠障碍、疲劳、生活质量和功能障碍。结果 TranS-C 组在抑郁症状 (p < .001, d = 0.84)、失眠严重程度 (p < .001, d = 0.77)、睡眠障碍 (p < .001, d = 1.15)、睡眠质量方面表现出显着改善。相关损伤（p < .001，d = 1.22）、疲劳（p < .001，d = 1.06）、焦虑症状（p = .004，d = 0.67）、生活质量（p < .001，d = 1.06） 0.71），以及相对于治疗后立即 CAU 组的睡眠日记衍生参数（ps < .05，d = 0.12-0.77）。在 12 周的随访中，这些治疗效果仍然显着。在 12 周的随访中，功能障碍也得到了显着改善。结论 TranS-C 在缓解成人重度抑郁症患者的抑郁症状以及睡眠和昼夜节律紊乱方面是有效且可接受的。 团体形式似乎是交付 TranS-C 的一种低成本、可广泛传播的选择。有必要对 TranS-C 进行进一步研究，以检验其对其他精神疾病的益处。 （PsycInfo 数据库记录 (c) 2024 APA，保留所有权利）。