Thin-film composite (TFC) membranes have gradually replaced some traditional technologies in the extraction, separation, and concentration of high value-added pharmaceutical ingredients due to their controllable microstructure. Nevertheless, devising solvent-stable, scalable TFC membranes with high permeance and efficient molecule selectivity is urgently needed to improve the separation efficiency in the separation process. Here, we propose phenolphthalein, a commercial acid-base indicator, as an economical monomer for optimizing the micropore structure of selective layers with thickness down to 30 nanometers formed by in situ interfacial reactions. Molecular dynamics simulations indicate that the polyarylate membranes prepared using three-dimensional phenolphthalein monomers exhibit tunable microporosity and higher pore interconnectivity. Moreover, the TFC membranes show a high methanol permeance (9.9 ± 0.1 liters per square meter per hour per bar) and small molecular weight cutoff (≈289 daltons) for organic micropollutants in organic solvent systems. The polyarylate membranes exhibit higher mechanical strength (2.4 versus 0.8 gigapascals) compared to the traditional polyamide membrane.

中文翻译：

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用于分子筛的基于 3D 酚酞的微孔聚芳酯膜


薄膜复合（TFC）膜由于其可控的微观结构，在高附加值药物成分的提取、分离和浓缩中逐渐取代了一些传统技术。然而，迫切需要设计具有高渗透性和高效分子选择性的溶剂稳定、可扩展的TFC膜，以提高分离过程中的分离效率。在这里，我们提出酚酞（一种商业酸碱指示剂）作为一种经济的单体，用于优化通过原位界面反应形成的厚度低至 30 纳米的选择性层的微孔结构。分子动力学模拟表明，使用三维酚酞单体制备的聚芳酯膜表现出可调的微孔率和更高的孔互连性。此外，TFC 膜对有机溶剂系统中的有机微污染物表现出较高的甲醇渗透性（9.9 ± 0.1 升/平方米/小时/巴）和较小的截留分子量（约 289 道尔顿）。与传统的聚酰胺膜相比，聚芳酯膜表现出更高的机械强度（2.4 与 0.8 吉帕）。