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Efficient reductive amination of 5-hydroxymethylfurfural by iridium-catalysed transfer hydrogenation
Catalysis Science & Technology ( IF 4.4 ) Pub Date : 2024-08-10 , DOI: 10.1039/d4cy00812j Haoying Liu 1 , Weijun Tang 1 , Dong Xue 1 , Jianliang Xiao 2 , Chao Wang 1
Catalysis Science & Technology ( IF 4.4 ) Pub Date : 2024-08-10 , DOI: 10.1039/d4cy00812j Haoying Liu 1 , Weijun Tang 1 , Dong Xue 1 , Jianliang Xiao 2 , Chao Wang 1
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Transfer hydrogenative reductive amination of 5-(hydroxymethy)furfural (HMF) has been accomplished, catalysed by a cyclometalated iridium catalyst with formic acid as a hydrogen source. The catalytic system afforded a TON of 9600 and TOF of 14 400 h−1, and the reaction can be successfully scaled up to a 10 gram scale at a substrate-to-catalyst ratio of 10 000. A wide range of amines could be coupled with HMF to afford furan derived products, including modified drug molecules, key intermediates for drug synthesis and potential monomers for polymer synthesis.
中文翻译:
铱催化转移氢化高效还原胺化 5-羟甲基糠醛
以甲酸为氢源,在环金属铱催化剂的催化下,实现了5-(羟甲基)糠醛(HMF)的转移加氢还原胺化。该催化体系的TON为9600,TOF为14 400 h -1 ,并且在底物与催化剂的比例为10 000的情况下,反应可以成功放大至10克规模。可以偶联多种胺。与 HMF 一起生产呋喃衍生产品,包括修饰的药物分子、药物合成的关键中间体和聚合物合成的潜在单体。
更新日期:2024-08-10
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
铱催化转移氢化高效还原胺化 5-羟甲基糠醛
以甲酸为氢源,在环金属铱催化剂的催化下,实现了5-(羟甲基)糠醛(HMF)的转移加氢还原胺化。该催化体系的TON为9600,TOF为14 400 h -1 ,并且在底物与催化剂的比例为10 000的情况下,反应可以成功放大至10克规模。可以偶联多种胺。与 HMF 一起生产呋喃衍生产品,包括修饰的药物分子、药物合成的关键中间体和聚合物合成的潜在单体。